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During the 7-day treatment schedule, MP-13 maintained stable antinociception without tolerance development, as evidenced by the unchanged microglial cell count in the periaqueductal gray, indicating that chronic exposure did not trigger neuroinflammatory adaptation—a process in which microglia become activated, release pro-inflammatory cytokines, and contribute to opioid tolerance

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But, if the FDA ultimately reclassifies these peptide therapies so they can be compounded, Kesselheim says patients will have no trouble finding doctors who are comfortable prescribing them for all sorts of conditions