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Supplement & Nutritional Therapy Supplements to prevent muscle cramps with the best evidence include: Magnesium glycinate or citrate—most effective for nocturnal leg cramps, toe cramps, and whole-body spasms related to electrolyte imbalance Potassium —particularly valuable for leg cramps at night and charley horses in athletes Vitamin D3 + K2—addresses deficiency-related myofascial pain and muscle weakness Vitamin B12—important for nerve health

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