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Additionally, we employed a genetic knockout of Caspase Recruitment Domain-9 (CARD9), which impairs the immune response against fungi
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Although these studies suggest RyR1 is affected by statins, ambiguity has remained on whether this is due to direct binding, by affecting an RyR1 binding partner (present in tissue and in SR vesicle preps), or by affecting signaling pathways that impinge on RyR1
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