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[00564] In a third set of embodiments of the method of the third aspect which can comprise the method of the third aspect performed according to the first set of embodiments or the second set of embodiments, providing a proteomically detectable genetic protein variation corresponding to the proteomically detectable genomic variation in the biological sample of the individual, is performed by: performing annotation on the proteomically detectable genomic variation in the biological sample of the individual to produce a corresponding mutant/reference protein sequence

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