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Damage to the BBB may offer an opportunity for the therapeutic access of anti-inflammatory drugs administered parenterally, however, a “leaky” BBB may still be a barrier to large anti-inflammatory molecules such as Serp-1 and M-T7, immunomodulatory proteins isolated from Myxoma virus, indicating the need for pre-clinical testing of each candidate anti-inflammatory compound [11]

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Variable modulation of opioid brain uptake by P-glycoprotein in mice