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Foretinib is a multi-target inhibitor for c-Met, AXL, RON, VEGFR2, and TIE-2 ( Tepotinib is an effective and highly selective c-Met inhibitor, and its c-Met selectivity exceeds that of most kinase inhibitors with a cell-based 50% inhibitory concentration (IC50) of 1.7 nM ( Capmatinib (INC280) is a highly selective c-Met inhibitor who has an IC50 of 0.13 nM for c-Met ( Several other similar c-Met inhibitors, such as golvatinib (E7050) and SU11274 have also been reported to have antitumor activity against HCC ( HGF/c-Met Signaling in Pancreatic Cancer Pancreatic cancer (PC) is a highly malignant disease with the worst prognosis due to its strong invasion and metastasis ability
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