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clozapine also inhibited Th1 differentiation by blocking the AKT activation pathway ( in vitro differentiation of Treg cells and the expression of Foxp3 in splenocytes and lymph node cells from C57BL6/J mice in a model of experimental autoimmune encephalomyelitis (EAE) ( Regarding the effects of clozapine in MQs it has been described that clozapine increased IL-10 production and decreased IL-12 secretion in MQs after 5 days of incubation and when it is stimulated with lipopolysaccharide (LPS) for 24 h ( In studies carried out in animal models, similar effects to those described above in cell cultures have been observed in MQs
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