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The affected gene networks include: Collagen synthesis: Upregulation of collagen types I, III, and V, the primary structural proteins of skin Elastin production: Increased elastin gene expression, supporting skin elasticity Glycosaminoglycan (GAG) formation: Enhanced production of hyaluronic acid and other GAGs that maintain skin hydration Decorin production: Increased expression of decorin, which regulates collagen fibril assembly and organization Antioxidant defense: Upregulation of superoxide dismutase and other antioxidant genes A 2018 follow-up study provided additional gene expression data supporting GHK-Cu's regenerative and protective properties, including suppression of genes associated with tissue destruction and fibrosis 2